PRP & Polynucleotides for Hair Loss: What Actually Works?

Hair thinning is one of the most common aesthetic concerns affecting both men and women. It can be caused by genetics, hormones, stress, nutritional factors, inflammation, or ageing. At Our Skin Clinic, we offer medically-informed, non-surgical treatments including PRP (Platelet-Rich Plasma), Plinest Hair Polynucleotides, and Exosome options to support the health of the scalp and hair follicles.

This guide explains what these treatments do, who they help, and what the science really says.

Why Hair Loss Happens

Common causes include:

• Androgenetic alopecia (male/female pattern hair loss)
• Telogen effluvium (stress-related shedding)
• Post-pregnancy shedding
• Hormonal changes
• Poor scalp circulation
• Inflammation around hair follicles

Recent research shows that inflammation, microvascular changes, and oxidative stress all contribute to weak or miniaturised hair follicles. Reference: Rossi et al., Journal of Cosmetic Dermatology, 2020. This is why regenerative treatments can help restore a healthier environment for growth.

1. PRP (Platelet-Rich Plasma) for Hair Loss

How PRP works: PRP uses a small sample of your own blood, which is spun to isolate platelets. Platelets contain growth factors such as PDGF, VEGF, and IGF. These support improved blood supply to hair follicles, reduced inflammation, stronger hair shafts, and prolongation of the hair growth phase (anagen).

Evidence (2015–2025): A large meta-analysis in 2021 found PRP to significantly increase hair density and thickness in androgenetic alopecia patients. Reference: Gentile et al., Journal of Cosmetic Dermatology, 2021. A 2017 trial showed 30–40% improvement in hair count after 3–4 sessions. Reference: Gupta et al., Dermatologic Surgery, 2017.

At Our Skin Clinic: PRP Hair Loss Management, Package of 3 sessions, Optional addition of Polynucleotides for enhanced regeneration.

2. Polynucleotides (PNs) — Plinest Hair

Polynucleotides (PNs) are fragments of purified DNA originally used in regenerative medicine to repair injured tissues.

How PNs support hair growth: PNs have been shown to increase fibroblast activity, improve microcirculation, reduce oxidative stress, calm inflammation around hair follicles, and support healthier, thicker hair growth.

Evidence: A 2023 study found polynucleotides significantly improved hair density and scalp hydration, particularly in early hair thinning. Reference: Ribeiro et al., Journal of Cosmetic Dermatology, 2023. PNs are especially beneficial for clients who have inflammation-based thinning or want a gentler regenerative approach.

At Our Skin Clinic: We offer Plinest Hair, often combined with PRP for deeper regenerative support.

3. PRP + Polynucleotides Combination

Many clinics now combine both PRP and PNs due to their complementary benefits.

• PRP → growth factors + blood supply
• Polynucleotides → regeneration + repair + anti-inflammatory effect

Evidence: A 2022 review highlighted that combined regenerative therapies may produce stronger improvements compared with single modalities. Reference: Cervelli et al., Aesthetic Medicine Journal, 2022.

At Our Skin Clinic: Our most comprehensive hair treatment option is Hair Restoration (PRP + Plinest Hair), with the option to add exosomes (Purasomes) for enhanced cellular stimulation.

4. Exosomes (Purasomes) for Hair Loss

Exosomes contain peptides and growth factors that can support follicle recovery.

Emerging evidence (2020–2024): A 2020 clinical pilot showed increased hair density with exosome therapy in early androgenetic alopecia. Reference: Shin et al., Stem Cell Research & Therapy, 2020. More research is ongoing, but results are promising.

At Our Skin Clinic: Clients can add Purasomes (exosomes) to hair sessions for enhanced rejuvenation.

Who Benefits Most from These Treatments?

Ideal candidates include clients with:

• Early or moderate thinning
• Stress-related hair shedding
• Genetic pattern hair loss (male/female pattern)
• Postpartum shedding
• Scalp inflammation
• Poor circulation

They are less effective for:

• Completely bald areas
• Long-standing hair loss where follicles have fully miniaturised

Treatment Plans at Our Skin Clinic

A typical protocol involves:

• 3 PRP sessions or 3 PN sessions over 12 weeks
• Optional exosomes
• Maintenance every 6 months
• Topical and nutritional support recommendations