Skin Boosters
Seventy Hyal vs Profhilo vs Plinest — Which Is Best for You?
A Clinically-Informed Guide from Our Skin Clinic | Published on
Skin boosters have become a leading option for clients seeking hydration, improved skin quality, and a natural glow without altering facial structure. At Our Skin Clinic, we offer several advanced bio-remodelling and biorevitalisation treatments, including Seventy Hyal, Profhilo, and Plinest (Polynucleotides).
Each treatment has different effects, indications, and biological mechanisms. This guide explains their differences using up-to-date scientific evidence.
What Are Skin Boosters?
Skin boosters are injectable treatments designed to improve skin hydration, elasticity, and texture. Unlike fillers, they do not create volume or structural change. Instead, they improve the skin quality itself.
Recent studies confirm that skin boosters can enhance dermal hydration, stimulate collagen, and support barrier function. Reference: De Boulle et al., Journal of Cosmetic Dermatology, 2020.
Seventy Hyal — High-Intensity Hydration
What it is: Seventy Hyal is a next-generation hyaluronic acid (HA) bio-stimulator designed to restore hydration and improve skin radiance.
How it works: Hyaluronic acid attracts water molecules into the skin, improving elasticity and plumpness.
Best for:
- Dehydrated skin
- Dull or uneven tone
- Early signs of ageing
Number of treatments: Usually 2–3 sessions.
Evidence: Studies in the last decade show HA-based boosters improve hydration and elasticity with minimal downtime. Reference: Pavicic et al., Dermatologic Surgery, 2019.
Profhilo — Bio-Remodelling for Firmness and Elasticity
What it is: Profhilo is a stabilised hybrid hyaluronic acid (H-HA and L-HA) formulation designed to stimulate firmness and remodel the skin.
How it works: Research shows that Profhilo triggers fibroblast activity, increases collagen types I and III, and improves skin laxity. Reference: Beco et al., Aesthetic Medicine Journal, 2021.
Best for:
- Skin laxity
- Crepey texture
- Clients seeking subtle lifting and tightening
Treatment protocol: Two sessions, 4 weeks apart.
Common areas treated at Our Skin Clinic: Face, Neck, Lower face (jowls), Hands.
Plinest (Polynucleotides) — Advanced Bioregeneration
What it is: Polynucleotides (PNs) use fragments of purified DNA to stimulate deep skin regeneration.
How they work: Recent studies show PNs improve Cellular repair, Dermal hydration, Elasticity, Tissue regeneration, and Inflammation reduction.
A 2023 review concluded that polynucleotides significantly improve dermal structure and are particularly effective for under-eye ageing and crepey skin. Reference: Ribeiro et al., Journal of Cosmetic Dermatology, 2023.
Best for:
- Fine lines under the eyes
- Loss of elasticity
- Sensitive or thinning skin
- Restoring skin function
- Long-term regenerative support
Why we use Plinest at Our Skin Clinic: It provides hydration and deep tissue repair without adding thickness or volume.
Comparing the Three Treatments
| Feature | Seventy Hyal | Profhilo | Plinest (PNs) |
|---|---|---|---|
| Main Action | Hydration | Firming + hydration | Regeneration + healing |
| Best For | Dull, dehydrated skin | Mild skin laxity | Under-eyes, fine lines, sensitive skin |
| Structure Change | None | Mild tightening | None |
| Sessions | 2–3 | 2 | 2–4 |
| Longevity | 3–6 months | 6+ months | Improving with each course |
Which One Should You Choose?
At Our Skin Clinic, your practitioner will assess:
- Skin thickness
- Hydration levels
- Elasticity
- Concerns (dullness, laxity, fine lines, under-eyes)
- Ageing pattern
- Treatment history
We often combine treatments — for example, Profhilo for firmness and Plinest for under-eye regeneration, or HA boosters with SkinPen microneedling for more dramatic improvement.